).82,83 Sufferers with MBL with mutated motorists have a shorter time for you to 1st cure compared to instances without having mutations. After CLL is recognized, The expansion dynamics of tumor cells is heterogeneous. Some sufferers exhibit a logistic-like conduct through which the clone stabilizes after a while, While some Other folks show an exponential- like progress pattern.84 This exponential development, clinically defined as “quick lymphocyte doubling time” remains to be viewed as an adverse prognostic parameter in CLL.
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